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A revolutionary examination of why we age, what it means for our health, and how we just might be able to fight it.
In Cracking the Aging Code, theoretical biologist Josh Mitteldorf and award-winning writer and ecological philosopher Dorion Sagan reveal that evolution and aging are even more complex and breathtaking than we originally thought. Using meticulous multidisciplinary science, as well as reviewing the history of our understanding about evolution, this book makes the case that aging is not something that “just happens,” nor is it the result of wear and tear or a genetic inevitability. Rather, aging has a fascinating evolutionary purpose: to stabilize populations and ecosystems, which are ever-threatened by cyclic swings that can lead to extinction.
When a population grows too fast it can put itself at risk of a wholesale wipeout. Aging has evolved to help us adjust our growth in a sustainable fashion as well as prevent an ecological crisis from starvation, predation, pollution, or infection.
This dynamic new understanding of aging is provocative, entertaining, and pioneering, and will challenge the way we understand aging, death, and just what makes us human.
- Sales Rank: #457927 in Books
- Published on: 2016-06-14
- Released on: 2016-06-14
- Original language: English
- Number of items: 1
- Dimensions: 9.48" h x 1.06" w x 6.38" l, .0 pounds
- Binding: Hardcover
- 336 pages
Review
"A thoughtful examination of the role of aging and death in supporting life." ―Kirkus Reviews
“Mitteldorf and Sagan take an extensive stroll through evolutionary theory and aging research in support of an off-center view… The authors may be on to something.” ―Science News
"Science proves it: You can turn back the clock and feel ten (or even twenty!) years younger. In their new book...Josh Mitteldorf and Dorion Sagan outline the groundbreaking findings and offer an easy-to-follow plan to prevent and reverse the signs of aging." ―Closer magazine
"Together Mitteldorf and Sagan slough off the old aging theories to make way for the new.... In many ways Cracking the Aging Code reminds me of On the Origin of Species―both work to overcome entrenched ideas...Mitteldorf is like a Darwin himself, full of questions about nature, plunging himself into thought against prevailing notions, making an intellectual voyage to the far ends of research to gather, with painstaking care, all the data needed to support the idea of group selection. For those readers who might not be aware of how scientific progress is made, I recommend this book because there is so much to be learned here from witnessing the struggle against orthodoxy, which is everything in science." ―Digital Journal
“This is the science book of the year, the best I’ve read in quite a while… Mitteldorf supplies abundant evidence for his theory and it makes for fascinating reading… Cracking the Aging Code should be required reading for anyone interested in aging or indeed evolution and biology.” ―Rogue Health and Fitness
"This truly revolutionary book presents a new view of aging: we don’t wear out; we are killed from within by genes timed to eliminate us for the good of the larger community. Are the authors right? They’re certainly persuasive, and the implications are staggering.” ―Carl Safina, Stony Brook University Endowed Professor for Nature and Humanity and author of Beyond Words: What Animals Think and Feel
“In Cracking the Aging Code, an enlightening and entertaining elucidation of senescence, you’ll learn the sad truth: we are prey to an inner assassin. The programmed self-destruction we call aging is an inside job. But authors Mitteldorf and Sagan still manage to find hope and offer practical advice to help you live long and prosper.” ―Julie Holland, MD, author of Moody Bitches: The Truth About The Drugs You're Taking, the Sleep You're Missing, the Sex You're Not Having, and What's Really Making You Crazy
“Cracking the Aging Code is the most original popular science book you’re likely to read this year. Josh Mitteldorf is a creative thinker and a master teacher. Whether you agree or disagree with the central premise―we are programmed to die―you’ll find that Cracking the Aging Code reshapes your understanding of profound issues concerning the genetic construction of life and death.” ―Peter D. Kramer, Clinical Professor Emeritus of Psychiatry and Human Behavior at Brown University and author of Ordinarily Well and Listening to Prozac
“Brilliant, challenging, rejuvenating...with dazzling, sagacious prose and fascinating, cutting-edge science, Josh Mitteldorf and Dorion Sagan take an extended and profound look at the pernicious problems of death and aging from all angles. If you love life and want to live more of it, Cracking the Aging Code is brimming with ideas that are broken down with patience and humor so even the less scientifically-minded can grasp what the great anti-aging researchers are grappling with today.” ―Susan Block, Ph.D., author of The Bonobo Way and director of the Dr. Susan Block Institute
“The authors have attacked one of the greatest paradoxes in the evolutionary sciences. If genes are so damned selfish, why do they code for the destruction of the bodies that carry them? This book includes many a fascinating, entrancing but real tale from nature. And it shows how every one of these pieces of evidence challenges us to answer the book's big question―why would genes code not just for survival but for an organism's annihilation?” ―Howard Bloom, author of The Lucifer Principle: A Scientific Expedition into the Forces of History and The God Problem: How a Godless Cosmos Creates
“How do we grow into old age?’ Josh Mitteldorf knows as much about this subtle question as anyone writing today, and his account is full of surprises. He and his coauthor, Dorion Sagan, have created a winning combination of biological literacy and civilized conversation, a true gift to the reader.” ―Angus Fletcher, Distinguished Professor Emeritus at The City University of New York Graduate School and author of The Topological Imagination: Spheres, Edges, and Islands
About the Author
Theoretical-biologist Josh Mitteldorf has a PhD from UPenn. He runs the website AgingAdvice.org, and writes a weekly column for ScienceBlog.com. Mitteldorf has had visiting research and teaching positions at various universities including MIT, Harvard, and Berkeley.
Dorion Sagan is a celebrated writer, ecological philosopher and theorist. His essays, articles, and book reviews have appeared in Natural History, Smithsonian, Wired, New Scientist, and The New York Times, among others.
Most helpful customer reviews
15 of 15 people found the following review helpful.
A convincing case for aging as a genetic program
By Daniel Lemire
Mitteldorf's theory of aging can be summed up as follows. We are programmed to age because it is beneficial to the species as a whole. Aging helps prune the herd and keep the food supply abundant.
What does it mean to say that we are programmed to age? It means that the body "knows" how to be young, but chooses to be old.
This makes aging a formidable foe since we are deeply wired to age... if some individuals could, through luck, fail to age, they would quickly take over the rest... At the same time, this suggests that if we know enough about how the body keeps "its aging clock", we could possibly reset it.
11 of 11 people found the following review helpful.
A superb study on the aging process
By stan bazilian
An excellent book on a very challenging subject.
I enjoyed this book very much, having been a student of longevity for 40 years.
Josh's book, among its many other strengths, is a studied examination of evolutionary concepts of aging, and how populations protect themselves from extinction by taking protective measures against overpopulation.
I also got some good tips on how we might lengthen our own lives as well as improve the quality of life, so we don't fall prey to illnesses that accompanies aging.
I feel that, far from being a flaw, this is a definite asset, in a great book.
I was most impressed with the discussion of the Demographic Theory of Aging, Josh's original concept; which explains many questions raised by this most intriguing subject.
4 of 4 people found the following review helpful.
An interesting scientific hypothesis-- with some politics and a touch of woo.
By M. Passey
The central hypothesis of this book is that aging is a group-selected adaptation that serves to “stabilize ecosystems, to level the death rate in good times and hard times.” This is a very interesting idea and I thought it was compellingly argued in this book. I wish Mitteldorf had gone into more technical detail on the scientific evidence--- maybe a chapter on the details of his research. There is something of an as-discussed-elsewhere flavor to the exposition. In fact, at the end he references his coming book Cracking the Aging Code “for academic biologists.”
There is a longstanding academic debate on the question of whether fitness selection pressure occurs in humans at a higher order of social organization than the individual, i.e. group selection. Because Mitteldorf’s hypothesis is a type of group selection, he takes it as necessary to defend the idea of group selection in general to support his specific hypothesis of aging. To be sure, the mainstream bias against group selection probably is a barrier to acceptance of this aging theory, “…the root of the scientific community’s failure to understand aging.” This is at least partly because the group selection controversy is often discussed in the context of the topic of human altruism. Mitteldorf wades into the controversy of whether strong altruism is a result of group level fitness selection pressure. This is a very interesting topic, but in my view distracts somewhat from his core thesis on aging.
In the first place, group selection in the broader sense has almost certainly occurred in evolution. Quoting Eugene Koonin from The Logic of Chance, “I posit that primordial evolution leading from small genetic elements to large genomes comparable to the genomes of modern cellular life forms appears to be all but impossible without some form of group selection.” On the face of it the evolution of multicellular organisms is a form of selection at successive hierarchical levels of complexity above individual selfish genetic elements. Plus, Mitteldorf convincingly argues that genetically programmed aging occurs in protists, nematodes, and fruitflies. None of this rides on the question of group selection for human altruism.
Mitteldorf then really goes on a tangent to indulge his personal views of the political implications of genetically programmed altruism; the fact that humans have selfish genes doesn’t imply genetically determined individual selfishness in the ordinary sense. So in a book on the science of aging we get some gratuitous political assertions. For just one example, “If they told the truth about their motives, the rapacious corporate giants could never sell deregulation to an enlightened democracy. So they promote the dogma of a ‘free market,’ not because they believe in this or any ideology but because it supports the freedom of the largest and the strongest to pillage everyone else. Historically, an important part of the argument for the benignity of free markets comes from the analogy with evolution.”
In my opinion, Mitteldorf is correct that the group selection explanation for altruism will eventually carry the day. (I particularly like Bowles and Gintis on this, A Cooperative Species: Human Reciprocity and its Evolution.) But strong altruism evolved to punish free riders as much as it did to help others in the ingroup. It is likely that in early humans intertribal conflict was a main pressure point for survival of the fittest group---kill the men of the neighboring tribe and steal their women and hunting grounds. Ingroup/outgroup psychology has been the basis for unspeakable acts of inhumanity. The study of human cooperation from the evolutionary perspective is the basis for a nascent evidence-based public policy, but it’s early in the process. For example, Elinor Ostrom’s Governing the Commons: The Evolution of Institutions for Collective Action is a primer on the topic of evidence-based public policy. It does not necessarily imply strong centralized regulation as the most efficient, fair or stable form of government. For the purposes of this book review I simply point out that altruism is a very complex topic far beyond the scope of this book. Mitteldorf’s interaction with the topic is necessarily perfunctory because it’s actually off topic. I think it somewhat distracts from the impact of his core arguments on aging.
Lastly is the topic of anti-aging remedies. It’s exciting stuff; I think I’m going to ask my doctor to put me on Metformin. But this topic is kind of a footnote to the rest of the book. Deservedly so since the science is so scanty. I think Mitteldorf could have been a little more explicit in delineating the degree of the evidence for any of the things he mentions. It starts to be a longish list of various things people are trying that may or may not pan out to prolong healthy lifespan.
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